I did a google
search for Sturgeon and found this written by a medical
A LACK OF CRITICISM FOR THE BRAND NAME DRUG
I am writing in response to your comment about using StugeronT for
seasickness - and your annoyance that the Federal Drug Administration
doesn't approve it for sale
in the United States.
I talked about medical
preparations for cruising at the 2006
Zihuatanejo SailFest, and used that opportunity to review medications
for seasickness - including StugeronT, which is a brand name for
cinnarizine. Even though many people have found that cinnarizine is
effective in preventing seasickness without noticeable side-effects,
it is not a good drug. Cinnarizine is a 'sloppy' drug that interacts
with at least three different receptors in the brain and the rest of
the body, histamine and acetylcholine receptors like most drugs for
seasickness, along with dopamine receptors. In addition, it is a
calcium channel blocker. Incidentally, almost all adverse effects of
cinnarizine are found by looking for information under the generic
name. There is very little literature criticizing the brand name drug.
Low-dose cinnarizine, 25 mg, is sold in many countries as StugeronT
(among more than 40 brands) for vertigo and motion sickness.
Cinnarizine is banned - even in low doses - by airline pilots in the
United States because it impairs judgement. Higher dose cinnarizine,
75 mg, is sold as Stugeron ForteT in countries where it is available,
and is used to relax arteries due to its calcium channel blocking
effects. High doses have also been reported to unmask Parkinson's
disease, or make Parkinson's disease worse due to blocking dopamine
receptors. Drugs that have such different uses with such small
differences in dose are just not good drugs - even if they are
effective in some instances.
In these many regards, cinnarizine is similar to other medications
taken for nausea and seasickness - including PhenerganT and
CompazineT, which are available in the U.S. and have similar physical
and psychological side effects. In fact, all of the drugs for
seasickness - including original DramamineT, meclizine (non-drowsy
DramamineT), and Transderm-scopT - have many significant side-effects
and need to be used with caution, especially if someone is operating
complex and expensive equipment
in situations where good judgment and
clear thinking are critical.
Cinnarizine is commonly sold in other countries as 25 mg tablets, but
it is usually effective at lower doses. Cinnarizine is not safe for
pregnant women, or children
younger than five. People who have taken
cinnarizine, and who have found it to work without side-effects,
should take the lowest effective dose. But they should consult their
physician, especially if they have Parkinson's disease, take
medications for depression, or have heart disease. Higher dose 75 mg
tablets of cinnarizine, such as Stugeron ForteT, are aimed at a
different problem than seasickness.
Don't hold your breath waiting for the FDA to approve it for sale
the United States.
Roy Verdery, M.D.
/ Santiago Bay, Mexico