I think the ICW
through Georgia and South Carolina is some of the most beautiful cruising in the Eastern U.S. And unfortunately, (or maybe fortunately), a lot of people pass it by and sail offshore
for that leg.
The beautiful anchorages
are too numerous to count. Cruiser's Net
has lots of them, but there are many others that aren't written up anywhere. Most of the time, insects are not a problem at all. But make sure you have adequate mosquito netting or screens, because when they do come, holy cow!
favorite is Price's Inlet just north of Charleston. You can go for a walk on the beach on Bull Island, which is even more fabulous than Cumberland Island (which is as fabulous as everyone else here says it is). Price's can get crowded with locals during the day on summer weekends, but is deserted in the evenings or most of the rest of the year.
And the Wacamaw River in South Carolina (which has several great anchorages) is simply magic.
A few favorites in Georgia over the years: Big Tom Creek, Walburg Creek, and the Brickhill River and Dungeness at Cumberland Island.