The best route
is east around Cuba, through the Windward Passage
. Then it's a straight shot to Bocas with the wind
at a more favorable angle. You will have about 4 days of motoring into the wind
getting around Cuba, but once you get below Hispaniola, you'll have the trade
winds pushing you.
If you go west and then to the Caymans, it's not as good a wind angle from there to Bocas.
We did the trip around the east side in 1012, and headed to Cartagena
instead of Bocas. Bocas would have been a much easier destination