Guess you will already be watching the weather so only other concern will be the Gulf Stream
. If a cold front aka norther blows in you will have the wind
from the north blowing against the Gulf Stream
flowing north and it can get really, really nasty.
By Charleston the Stream is pretty far offshore
but the further south you go the closer in the edge of the Stream. Hug the US coast as much as practical to stay out of the current
, maybe even pick up some counter current
One thing that annoyed me on that trip was the number of unlit buoys off the coast, some 5-6 miles off or more if I recall
. Keep a good watch, use radar
if you've got it.