I don't know about performance difference, at least measurable. However, one thing I like to do is use a different color between the first and second coat to use as a wear indicator. If the first coat is blue and the topcoat red, I know I need to really start thinking about a bottom job when the blue starts showing through.
By the way, don't forget some extra coats at the waterline and the leading edge of the keel
. Those areas wear fastest.