Huh. You are going to have a hard time checking all those
destination boxes with one "perfect"
boat. The Brewer designs in the 40-50 foot range are well-proven and popular, but as most are farmed out as designs and not "factory" builds, you really have to see one, preferably with a locally hired
surveyor, to judge if the build equals the blueprints.
The boat I would choose for NWP and any Southern Cape is not the boat I would choose for the
Caribbean. If I were to stay only island-hopping, I would pick a
PDQ or South African
catamaran.
Look at my steel pilothouse cutter: it's in the same headspace as a few of the Brewer designs. That I would take to the Arctic or the Antarctic, and yes, part of that is the pilothouse. Note that many pilothouses contain pilothouse berths, a place to sleep offwatch that is nonetheless near the "action".
Sailing qualities are less important at sea. You want to be able to heave to and to have a smooth ride and fast isn't as important as keeping going. Some will argue that the ability to do eight instead of seven knots at 40 feet
LOA will keep you out of bad
weather, but if a storm is doing 12 knots, you're getting hit and you want a boat that can deal with that.
Check out Ted Brewer's website. He replies to e-mails, too.