There is a high in the way so your first decision is which side you want to go.
Above - warmer,
wind usually gets lighter as you go North and mostly E or SE, chance of 1000 miles or more to windward, the last leg is huge with around 4 weeks at sea, maybe stop at
Fiji Cooks
Marquesas
Below - colder, you sail downwind with the 40's at around 35 - 40S all the way to
Chile, the
wind is stronger and more reliable, check out a few
ports in southern and central
Chile, the North coast of Chile is notorious for light air, the wind up the coast of Chile is mostly S all the way to
Galapagos if you keep well
offshore, maybe stop off at Lima.
Yet again the answer is