Panama to San Andreas is certainly do able (especially with plenty of range under power), though
Cartagena gives you a better
wind angle, but after that getting to Jamaica/DR takes you much harder to windward. It is a common
route to loop further West thru the NW Carib and then easterly over
Cuba. You might take a look at that as an option.
colemj, another
member here, recently sailed Panama to
Jamaica, but the windward performance of his
Manta is likely better than the Solaris.