Beside the "Thorny Path" through the Bahamas to Turks & Caicos then the D.R. the Puerto Rico
to the V.I. There is the direct route which is nicknamed taking "I-66".
"I-66" is normally taken from the northern or central Bahamas heading east or east north east to longitude 066 west then turn right and head
south to the USVI's or Puerto Rico.
If you look at the Atlantic Pilot Charts
you will see that you need to stay at or north of latitude 25 degrees to keep in the winds from the west. Further south you encounter the trade
winds marching westward which makes heading east very difficult.
The "I-66" route is about 1000nm to 1100nm depending upon how far you need to track north to stay out of the trade
winds until you read 66West. At about 6 kts you are looking at a week to 10 days at sea so you should be prepared for at least one good "blow/storm" enroute.