You will do better if you have the Keys Chart Pack, you can get at West
Marine; easy to run aground and hard to find the
anchorages without it. It is also not easy in the dark if you are inexperienced.
At 5 knots its 25 hrs and your more likely to average less than that, more like 3-4 days especially if you go up the
ICW which is as twisted as a dog's hind leg.
I have done it many times on my F31 tri and I always took at least 2 days, unless I did it outside the reef where there is a
knot of northerly
current.
Easier to go up Hawkes Channel but not as many places to
anchor. Rodriguez Key. Tavernier Key, Whale Key, inside of Snake Creek are all ok if the
weather is OK but
the holding is poor throughout the Keys.
Then if you draw 6ft or less go into Biscayne Bay at the top of
Key Largo at Angelfish Creek but strong tidal flow up to 3 knots. You can
anchor behind Pumpkin Key, or going north there is Elliot Key and Boca Chica. Near
Miami you can anchor near Dinner Key or just south and east of Rickenbacker Causeway. There are two narrow 'channels' in the middle of the Bay,
Cutter Bank and Feather Beds and it is shallow out of the channel.
There are a few
marinas on the outside, several on the inside you can find in the chart pack (Ocean Reef marina is $7/ft)
Good luck and if you have any specific questions send a private message.
Phil