You will do better if you have the Keys Chart Pack, you can get at West Marine
; easy to run aground and hard to find the anchorages
without it. It is also not easy in the dark if you are inexperienced.
At 5 knots its 25 hrs and your more likely to average less than that, more like 3-4 days especially if you go up the ICW
which is as twisted as a dog's hind leg.
I have done it many times on my F31 tri and I always took at least 2 days, unless I did it outside the reef where there is a knot
of northerly current
Easier to go up Hawkes Channel but not as many places to anchor
. Rodriguez Key. Tavernier Key, Whale Key, inside of Snake Creek are all ok if the weather
is OK but
the holding is poor throughout the Keys.
Then if you draw 6ft or less go into Biscayne Bay at the top of Key Largo
at Angelfish Creek but strong tidal flow up to 3 knots. You can anchor
behind Pumpkin Key, or going north there is Elliot Key and Boca Chica. Near Miami
you can anchor near Dinner Key or just south and east of Rickenbacker Causeway. There are two narrow 'channels' in the middle of the Bay, Cutter
Bank and Feather Beds and it is shallow out of the channel.
There are a few marinas
on the outside, several on the inside you can find in the chart pack (Ocean Reef marina is $7/ft)
Good luck and if you have any specific questions send a private message.