I normally think of the lake as a place to get across to get to the other side.
I suspect many who will answer will see it the same way... especially since it is often a concern in trip planning for it's
depth. If it were in some inland state, it might be considered a great sailing
destination... but it is not. It is in
Florida, some of the most popular cruising grounds in the world.
That said... there is no reason it could not be a great place to do what you propose...
You might look at Indian Town.... good base of operations and close to the lock to get out on the lake...