From Galveston area, you could make passage SW (540 n.m.) down to Puerto Yukalpeten yacht harbor (near Progreso), then coast hop ENE along the N shore of
Yucatan, round Catoche to the Isla Mujeres area. Then head down the
Yucatan Channel to
Belize, Rio Dulce, Roatan, wherever. Yes, it's tough getting around Cabo Gracias a Dios. ... Or, if you're really in
cruise mode, perhaps you would want to coast hop from Galveston S down to Rio Tuxpan and Veracruz, then cross E (340 n.m.) to Celestun nature park (flamingoes) in Campeche, then up to Puerto Yukalpeten. ... November is usually a good time to
work eastward in the
Gulf of Mexico and Western Caribbean, because the easterly
Trade Winds are not yet fully back in force after the end of
hurricane season. By January, Feb and March they can be full blast. My cruising guidebook "Cruising
Ports: the Central American Route" will be out in its 7th edition this spring, and it covers all these routes and destinations, including Panama. Have fun!