We get air in the lines when a tank goes empty. The
pump is self priming so it should only require running a faucet for a minute or two. This gets most of the air out, the remaining bubbles come out with use in the other faucet - if there are no
leaks. We run the faucet in the port rear bathroom as this has the shortest hose run.
A couple of points though, air can get in the system from a poor hose connection, they should all be double clamped. The water strainer cap can also allow air in if O ring has failed or lid is cracked from over-tightening. Also ensure the transfer valve is set entirely to port or starboard if one tank is empty. (Maybe worth opening the pressure relief valve on the hot water tank too - don't know if that would be an air issue or not).