What do you mean by 'not respond'. Does it freeze at some point? If so, what are you doing when it "does not respond"? Do you understand the controls for the program? Have you had bsb charts
running and visible? These problems are contextual ones, so you must be specific too, so people can help.
When first staring up, I found that referring to the online User Manual was very helpful.OpenCPN User Manual | Official OpenCPN Homepage
My guess is that this has something to do with your charts.