A few years ago I did use 5200 when I replaced the floor in an old Hypalon
Zodiac -- one that was well past its use-by date. Being the cheapskate that I am, I used some HErculite material that I had on hand for the replacement floor, and Herculite is a PVC based
fabric. The method I used was to leave the old floor in place and glue a
single piece of the new material over it. This isn't what a pro would have done, but it seemed the most likely way to not distort the shape of things.
The 5200 did successfully bond the two materials together, and I got several years of additional use out of the dink. But, using the 5200 was a PITA due to its very slow cure rate (took a week!). On this old
dinghy it was hard to keep it inflated continuously, and as it slowly sagged the new floor would move around, getting misaligned. It also pissed off our friends who had kindly loaned us their as yet unfurnished living room in their brand new house... we'd innocently told them we'd have it done in one weekend!
So, in my not quite professional opinion, Sikaflex 291 might well be a better choice of
adhesive... or some other rapid cure analog. I've used SC2000 two part glue very successfully on smaller
repairs, but the difficulty of getting a large thing like a whole floor aligned correctly with an "instant stick" contact glue is a real problem for an inexperienced person. With the Sika you will have a period where you can move things around and get good alignment, but still have it set up in a reasonable time.
Good luck with your
project, whatever you decide to use.
Cheers,
Jim