Well my first question is if you are considering the trip why not look at a chart to get an idea of the distances, ports
, stopovers, etc? Maybe I misunderstand but it seems to me that if you have to ask a bunch of strangers on the internet
about the most basic part of a pretty serious off shore trip then my advice is to think very carefully about your experience and capability to handle the trip.
Without getting out the dividers it is about 2500 nm Cabo to Panama
City, about 1500 nm Coion to W FL and these are straight line distances. First thing I would check is fuel
capacity and max range of the boat.
Unless you follow the gulf coast
around (much longer trip) you will have a hop of +/- 500 nm from Isla Mujeres to FL so you need range to do that plus a significant reserve.
Never been in the Pacific (at least not in a boat) but the run north from Colon to FL can be pretty rough depending on the time of year. Don't forget hurricane