I work in an ER and given that it is norovirus season here I have been an expert at treating nausea and vomiting. That said nausea and vomiting from gastroenteritis, chemotherapy, etc are very different from nausea and vomiting caused by motion sickness. Zofran is a great drug but expensive and it does not work for motion sickness.
There are 4 main classes
of antiemetics: 5HT3 receptor antagonists (zofran), dopamine antagonists (phenergan, stugeron), antihistamines (bonine, meclizine, dramamine, phenergan, stugeron) and anticholinergics (scopolamine). Phenergan and stugeron are both dopamine antagonists and antihistamines.
5HT3 receptor antagonists are great drugs and have less side effects than the other classes
but because of their mechanism of action only help with specific types of nausea- NO GOOD FOR MOTION SICKNESS.
For motion sickness the dopamine antagonists, anticholinergics and antihistamines are much more effective. One advantage of the dopamine antagonists is that they allow more rapid acclimation. The down side of all of these drugs is sedation and rarely movement disorders referenced above.
Nasa uses primarily scopolamine and even a combination that they refer to as scop-dex. This is 0.4 mg of scopolamine and 5 mg of dexedrine. Dexedrine is a stimulant and you will probably have a hard time explaining to your physician why you want a prescription for dextroamphetamine. The reality is though that this is very effective.
I think that phenergan and stugeron in low doses (12.5 mg) and bonine are safe and effective. They are sedating and you should try them out before using them offshore
and check with your dr. to make sure that there are no interactions with other meds you are on.
All of the other stuff like avoid alcohol, minimize caffeine, avoid excessive fatigue, stay on deck or with a view of the horizon when awake, don't be over or under fed are important. Remedies like pressure point wrist bands and ginger are effective for many and safer than pharmaceuticals.
For BobandConnie THC is an excellent antiemetic but not so great for side effect profile. If you have nausea and vomiting and are sitting on the couch watching TV in Washington
state it may be perfect....