Its against the prevailing NE and SE trades.
To go west you need to be 40N or 40S give or take to get decent westerly winds, and its very windy and bumpy most of the way.
Can and has been done, but not very common.
2002 I did Guam
to Ensenada departed mid March great trip but one hell of a ride. We were a big boat (100ft) with 12 crew and well set up for the sail. We averaged 25-35 kts plus winds for the majority of the westing. Biggest winds and seas I've ever experienced.
Not sure I'd wana do what we did in a boat much smaller mind...