I normally think of the lake as a place to get across to get to the other side.
I suspect many who will answer will see it the same way... especially since it is often a concern in trip planning for it's depth
. If it were in some inland state, it might be considered a great sailing destination
... but it is not. It is in Florida
, some of the most popular cruising grounds in the world.
That said... there is no reason it could not be a great place to do what you propose...
You might look at Indian Town.... good base of operations and close to the lock to get out on the lake...