"Sailing" the Amazon would be impractical, due to it's convoluted course. Motoring the Amazon would be quite practical.
No bridge spans the Amazon river.
Transatlantic ships call regularly at Manaus, nearly 1,600 km (1,000 mi) upstream; and smaller ships can reach Iquitos, Peru
, 3,700 km (2,300 mi) from the river's mouth, the farthest point from sea of any port serving ocean traffic. The width of the Amazon at Iquitos is about 2 km (1-1/4 mi). The mean depth
of the current-canal of the Amazon is between 40 and 50 m (or up to 150+ feet deep), and in places, over 100 m (over 300 feet) deep.
River steamers of more modest tonnage navigate on more than 100 of the larger tributaries.
Despite the low slope of the Amazon, the river currents can be surprisingly strong. In the lower Amazon (with the lowest slope), current
speeds range from 1 - 2 knots at low water
, and twice that at flood stage. In localized areas, currents can exceed 6 knots.