Yes. The tidal streams are stronger, the tidal range is greater, and there are many fewer ports
on the (beautiful, wild) French side.
If you are transiting non-stop it probably doesn't make much difference to you, other than the facts that (a) few all-tide ports
of refuge on the French side; (b) stronger tidal streams mean greater wind-over-tide problems in bad weather
If you want to day sail a tide at a time, you can do that on the UK side without risk and without extremely precise planning. There are lots of all-tide ports you can tuck into if the weather
You can do it on the French side, too, and your single-tide runs will be longer because of the stronger streams. But you have to plan it carefully because there are many fewer all-tide ports, and many of them are pretty far up rivers. Anchoring
is tricky due to the enormous tidal range (reaching 15 meters around St. Malo).
In fact in the entire Bay of St. Malo there isn't really a single
all-tide port (leaving aside the Channel Islands). You have to lock into St. Malo itself in a narrow time range around HW. There is a marina outside the lock, however, if your boat isn't too big or deep for it. You have to go all the way around to Cherbourg, and to get there you have to run the infamous Alderny Race
or sail a long way around it. I have to say, however, that it is unbelievably beautiful there.