As I mentioned I have anchored near Pumpkin Key many times, and passed through Angelfish even more times. Here is what I think:
Mosquitoes: there has only been one time when they were really bad, and I mean they were everywhere. When I went on deck
the next morning, the deck
was literally covered in mosquitoes that had landed in the heavy dew. Nonetheless, most of the time there are just a few mosquitoes about (remember, this area is the exclusive playground of the very wealthy, and they are generally well controlled - the mosquitoes, I mean...), and simple repellent is enough. Sometimes they are almost non-existent.
: as I mentioned, in my opinion the controlling depth is somewhere around 5-1/2 feet, maybe 5'3" (and becoming less). You should certainly be OK at half tide or better, the problem is figuring out when that is, because the nearest tide station (Ocean Reef) clearly has very different tide times. There have been many occasions when the tables said I should be going through at a slack and the water is clearly running strongly. So I would say that near high tide at Ocean Reef, with the tide still coming in, would be the safest bet for you.
The only place to be concerned about with 6' is the area just inside #1 and #2. Pete